Focal osseous dysplasia fod is one of the benign fibroosseous lesions of the jaw bones and the most commonly occuring benign fibroosseous lesion. Florid cementosseous dysplasia of maxilla and mandible. Fibro osseous lesions comprise a group of disorders characterized histologically by replacement of normal bone by cellular fibrous tissue within which varying amount of predominantly woven bone and acellular islands of mineralized tissue develops. Fibroosseous lesions fols are a poorly defined but pathologically diverse group of lesions affecting the craniofacial bones and jaw. Cementoosseous dysplasia lesions may be expansile when associated with bone cysts or osteomyelitis fig 6. Such lesions are characterized by replacement of normal bone with cellular fibrous tissue and newly formed osseous cementoosseous deposits.
Fibro osseous lesions are a diverse group of processes that are characterized by replacement of normal bone by fibrous tissue containing a newly formed mineralized product. Some may be part of more generalized systemic disease. Special emphasis on satb2 expression in osseous lesions of. Fibroosseous lesions of the jaws comprise a diverse group of conditions, which are characterized by replacement of normal bone by fibroblasts, collagen fibers, and mineralized tissue. Fibro osseous lesions 1 fibro osseous lesions dr shabeel pn 2 introduction. Introduction the term fibroosseous lesions fol has been used for many years as a general description for a group of.
This matrix displays varying degrees of mineralization in the form of woven bone or of cementumlike round acellular intensely basophilic structures. Get a printable copy pdf file of the complete article 1. Commonly included among the fibroosseous lesions of the jaws are fibrous dysplasia, cemento osseous dysplasia, and ossifying fibroma. Management and treatment outcomes of maxillofacial fibro.
Request pdf fibroosseous lesions of the face and jaws maxillofacial fibroosseous lesions fol consists of lesions that differ, with the exception of fibrous dysplasia, to those found in the. The florid variant may involve the entire mandible 6. They represent a group of diverse diseases characterized by similar histopathologic features, 6. Benign fibroosseous lesions of the craniofacial skeleton bfol are a variant group of intraosseous disease processes that share similar microscopic features characterized by hypercellular fibroblastic stroma containing various combinations of bone or cementumlike tissue and other calcified structures 16. Fibroosseous lesions are a poorly defined group of lesions affecting the jaws and craniofacial bones. Jan 31, 2017 fibrous dysplasia is a tumor like developmental condition, characterised by proliferation of abnormal cellular fibrous connective tissue with irregular trabe. Nov 28, 2005 fibro osseous lesions are a poorly defined group of lesions affecting the jaws and craniofacial bones. Journa of enta an ra eath 9 s e e pwt scientonlineorg ent oral ealth issn 23 research article scient open access exploring the world of science pattern of fibroosseous lesions of the jaws in kano, northern nigeria sule aa 1, iyogun ca2 and adeyemi te3 1department of pathology, bayero university kano aminu kano teaching hospital, kano.
Pattern of fibroosseous lesions of jaws in port harcourt in southsouth nigeria authors. Fibro osseous lesions classifications, pathophysiology. Fibroosseous lesion fol is a broad term for a diverse group of jaw and craniofacial disorders that are often painless but grow progressively if uncontrolled. This chapter demonstrates the variation in the radiological appearances of conditions of fibro.
Fibro osseous lesions of jaws dental implant courses by. Whereas some are diagnosable histologically, most require a combined assessment of clinical, microscopic and radiologic features. Furthermore, distant metastasis should be checked through chest and abdominal ct scans every 3. It will become apparent that for this group of conditions, diagnosis. Most common fibroosseous lesion encountered in clinical. Fibroosseous lesions are a group of bone disorders in which the. Fibroosseous lesions of jaw are a diverse group and since it may not be possible to adequately separate them. Fibroosseous lesions in adults have been well documented in many studies and although they often occur in children and adolescents, relevant reports are rather infrequent. Cementoosseous dysplasia may occur in the toothbearing jaw after dental extraction, and when multiple lesions are present, adjacent periapical lesions may coalesce. Recent world health organization classification 2005 for fibroosseous lesions was considered while subdividing these into. Radiographically, fibroosseous lesions vary considerably from a simple radiolucent lesion to mixed radiolucent radiopaque or radiopaque lesion. Case reports have been published on families presenting. Fibroosseous lesions the term fibroosseous lesion fol is a generic designation of a group of jaw disorders characterized by the replacement of bone by a benign connective tissue matrix.
Fibro osseous lesions classifications, pathophysiology and. The brown tumor of hyperparathyroidism, a giant cell lesion, may be encountered anywhere in the skeleton in both primary and. Fibroosseous lesions are characterized by the presence of bone marrow that has changed into fibrous tissue and that contains mineralized material of varying appearances. Whereas some are diagnosable histologically, most require a combined assessment. Focal osseous dysplasia europe pmc article europe pmc. In this study, we examined the epidemiological, clinical, and path. Fibro osseous lesions of jaw are a diverse group and since it may not be possible to adequately separate them. The benign fibroosseous lesions bfol represent a clinically diverse group of disorders of bone that share similar histopathologic features.
Fibroosseous lesions 1 fibroosseous lesions dr shabeel pn 2 introduction. Mdm2 and cdk4 immunohistochemistry is a valuable tool in the differential diagnosis of lowgrade osteosarcomas and other primary fibroosseous lesions of the bone. Fibrous dysplasia pathogenesis and histopathology youtube. All are characterized by the replacement of bone by cellular fibrous tissue containing foci of mineralization that vary in amount and appearance. Fibroosseous lesions fol represent a varied group of entities in which the normal bone is replaced by cellular fibrous tissue containing mineralized foci that may vary in amount and appearance.
The diagnosis based on microscopy alone is often impossible due to overlapping of histopathologic features. Fibro osseous lesions fol are a poorly defined group of lesions affecting the jaws and craniofacial bones. Clinical study of benign and malignant fibrous osseous lesions of the jaws 33 of follow up, 5 of 8 cases survived. Iadvances in omfs 19431993 j oral maxillofac surg 51. The article pitches a bright on the various classification systems are. Nov 20, 2014 benign fibroosseous lesions of the craniofacial skeleton bfol are a variant group of intraosseous disease processes that share similar microscopic features characterized by hypercellular fibroblastic stroma containing various combinations of bone or cementumlike tissue and other calcified structures 16. Nov 30, 2014 fibroosseous lesions the term fibroosseous lesion fol is a generic designation of a group of jaw disorders characterized by the replacement of bone by a benign connective tissue matrix. Other cementoosseous dysplasias defined as lesions which share some of the features of periapical cemental dysplasia andor florid cementoosseous dysplasia, but do not have their characteristic clinicopathological patterns of. Fibrous dysplasia may present with painless facial swelling and asymmetry.
Fibro osseous lesion fol is a broad term for a diverse group of jaw and craniofacial disorders that are often painless but grow progressively if uncontrolled. Dental college, regional institute of medical science, imphal, india. The term fol is a generic designation of a group of bone disorders characterized by the replacement of bone by a benign connective tissue matrix that displays varying degrees of mineralization in the form of woven bone or cementum. Benign fibroosseous lesions bfol are relatively frequently observed yet most cases are sporadic in the jaws. Among them, fibrous dysplasia has been reported to result from activating mutations of the gnas1 gene encoding the subunit of stimulatory g. Cementoosseous dysplasia occurs in the tooth bearing areas of the jaws. Molecular diagnosis of fibroosseous lesions of the oral. Fibroosseous lesions of the jaws in ibadan, nigeria. These group of lesions predominantly affects the jaws and craniofacial bones. This entity occurs more commonly in females and has a predilection for african americans. Fibroosseous lesions are grouped together because histologically they show similar cellular and mineralization patterns. Other cemento osseous dysplasias defined as lesions which share some of the features of periapical cemental dysplasia andor florid cemento osseous dysplasia, but do not have their characteristic clinicopathological patterns of presentation.
Ossifying fibromas are typically encapsulated, circumscribed, benign neoplasms made up of highly cellular fibrous connective tissue that contains varying amounts of osteoid, bone, cementum. Oct 28, 2016 fibro osseous lesions are grouped together because histologically they show similar cellular and mineralization patterns. Benign fibro osseous lesions is a group of lesions in which normal bone is replaced initially by fibrous connective tissue and over a period of time, the lesion is infiltrated by osteoid and cementoid tissue. Fol is a generic designation given to a group of disorders ranging from inflammatory to neoplastic that microscopically exhibit, a connective tissue. Fibroosseous lesions comprise a group of disorders characterized histologically by replacement of normal bone by cellular fibrous tissue within which varying amount of predominantly woven bone and acellular islands of mineralized tissue develops. Pattern of fibroosseous lesions of jaws in port harcourt. Fibroosseous lesions of the jaws comprise a diverse group of conditions, which are characterized by replacement of normal bone by. Clinical study of benign and malignant fibrousosseous lesions of the jaws 33 of follow up, 5 of 8 cases survived. Focal osseous dysplasia fod is one of the benign fibro osseous lesions of the jaw bones and the most commonly occuring benign fibro osseous lesion. Cod denotes an extensive process with multifocal involvement of the jaws by lesional tissue with the same microscopic. Clinical study of benign and malignant fibrousosseous. Fibroosseous lesions of the oral and maxillofacial. They are mostly characterized by the replacement of bone by a benign connective tissue.
Fibroosseous lesions of the face and jaws request pdf. Ossifying fibromas are typically encapsulated, circumscribed, benign neoplasms made up of highly cellular fibrous connective tissue that contains varying. Journa of enta an ra eath 9 s e e pwt scientonlineorg ent oral ealth issn 23 research article scient open access exploring the world of science pattern of fibro osseous lesions of the jaws in kano, northern nigeria sule aa 1, iyogun ca2 and adeyemi te3 1department of pathology, bayero university kano aminu kano teaching hospital, kano. Benign fibro osseous lesion bfol is a distinct group of jaw entities composed of fibrocellular tissue and mineralized materials. Maxillofacial fibroosseous lesions current diagnostic. Fibroosseous lesions fols are the group of lesions which are recognized to affect the jaws and the craniofacial bones which are known for their confusing area in diagnostic pathology.
Fibroosseous lesions fol are a poorly defined group of lesions affecting the jaws and craniofacial bones. Victor boyko presented a case of osteofibroma of the mandible associated with leontiasis ossea of the skull boyko gv. As a group, they are relatively common in the craniofacial complex, especially the jaws. Fibro osseous lesions fol represent a varied group of entities in which the normal bone is replaced by cellular fibrous tissue containing mineralized foci that may vary in amount and appearance. Introduction the term fibroosseous lesions fol has been used for many years as a general description for a group of tumors and proliferative disorders, which. Benign fibro osseous lesions bfol are relatively frequently observed yet most cases are sporadic in the jaws. Benign fibroosseous lesions bfol of the jaw, facial and skull bones are a variant group of intraosseous disease processes that share microscopic features 14. Atlas of oral and maxillofacial radiology electronic. Fibro osseous lesions of jaws were more in females 61. Fibro osseous lesions are characterized by the presence of bone marrow that has changed into fibrous tissue and that contains mineralized material of varying appearances.
Benign fibroosseous lesion bfol is a distinct group of jaw entities composed of fibrocellular tissue and mineralized materials. Benign fibro osseous lesions occur commonly in the jaw. Shiping wang and yifang zhao, benign fibro osseous lesions of the jaws. Pattern of fibro osseous lesions of jaws in port harcourt in southsouth nigeria authors. The classification of fol of the jaws has been an issue over time and. Apr 27, 2014 fibro osseous lesions of the jaws as a generic term used to describe a number of apparently different pathologic entities that commonly affect the maxilla, mandible and other facial bones1. Florid cement osseous dysplasia of maxilla and mandible. Waldron, dds, msd in the first volume of the journal of oral surgery, dr g. Pattern of fibroosseous lesions of jaws in port harcourt in.
A clinicopathologic analysis of 207 cases of benign fibro. Fibrous dysplasia is a tumor like developmental condition, characterised by proliferation of abnormal cellular fibrous connective tissue with irregular trabe. Fibroosseous lesions of the oral and maxillofacial region. Growth of lesion usually ceases at the end of skeletal growth. These form a diverse group of conditions with differing aetiologies but similar histological appearances.
Fibro osseous lesions of the jaws comprise a diverse group of conditions, which are characterized by replacement of normal bone by fibroblasts, collagen fibers, and mineralized tissue. Whereas some are diagnosable histologically, most require a combined assessment of. The disease involves the normal architecture of bone is replaced by fibrous tissue containing varying amount of foci of mineralization. They are characterized by the replacement of normal bone by fibrous connective tissue matrix displaying varying degrees of mineralization in the form of woven bone or cementumlike structures.
Despite the histologic ubiquity, their behaviors vary significantly. Benign fibroosseous lesions is a group of lesions in which normal bone is replaced initially by fibrous connective tissue and over a period of time, the lesion is infiltrated by osteoid and cementoid tissue. Fibroosseous lesions of the head and neck diagnostic. Benign fibroosseous lesions occur commonly in the jaw. Benign fibroosseous lesions bfol of the jaw, facial and skull bones are a variant group of intraosseous disease processes that share microscopic features 1 4. Classification and, therefore, diagnosis of these lesions is difficult because there is significant overlap of clinical and histological features. Jonathan swift 1667 1745 benign fibroosseous lesions.
Fibro osseous lesions of the jaws as a generic term used to describe a number of apparently different pathologic entities that commonly affect the maxilla, mandible and other facial bones1. Benign fibroosseous lesions of the jaws pocket dentistry. The aim of the study was to detect satb2 expression in os and other bony lesions of the jaw to analyze its diagnostic value. Fibro osseous lesions fols are a generic designation of poorly defined group of lesions which are recognized to affect the jaws and the craniofacial bones which are known for their confusing area in diagnostic pathology. Continuous observations on osteosarcoma and ewings sarcoma are very important and should be checked every two months after surgery. Benign fibroosseous lesions of the jaws request pdf. Summary this chapter demonstrates the variation in the radiological appearances of conditions of fibro. The purpose of this retrospective study was to evaluate the characteristics, treatment outcome of benign fibroosseous lesions of the jaws, in children, adolescents and adults. Ppt fibroosseous lesions powerpoint presentation free. Fibroosseous lesion is a generic designation for a clinically diverse group of bone disorders in which the lesional tissue consists of large volumes of fibrous connective tissue, principally collagens type i and iii, as well as an osseous component in the form of woven or lamellar bone or cementum with varying degrees of mineralization. Because of the histologic similarity and the broad range of morbidity among them, it is important to be able to differentiate between them in the. Differential diagnosis of fibrous dysplasia and fibro osseous neoplastic lesions of the jaws and their treatment. Benign fibro osseous condition involving one or more bones of the cranial and extracranial skeleton, consists of nonencapsulated lesions which show replacement of normal bone by cellular fibrous tissues edwards 1984 originally introduced by lichtenstein in 1938 one of the most perplexing diseases of osseous tissues.
Cysts and cystlike lesions involving the jaws fibroosseous lesions of the jaws benign tumours involving the jaws malignant lesions involving the jaws vascular anomalies of the mid and lower face. F ibrous dysplasia fd is the most common benign fibro. Five osseous lesions of the jaw were evaluated, including 2 oss one arising in fibrous dysplasia, and the other fibroblastic variant, one fibrosarcoma arising in ameloblastoma, and two fibromyxomas of mandible. Such lesions are characterized by replacement of normal bone with cellular fibrous tissue and newly formed osseous cemento osseous deposits. Fibroosseous lesions, africa, bone dysplasia, fibrous dysplasia, molecular diagnosis, ossifying fibroma.